Non-urgent advice: Note
This website is intended for healthcare professionals only.
EVIS is a UK multicentre study of Early Vasopressors In Sepsis, funded by NIHR and sponsored by NHS Greater Glasgow and Clyde.
The study is a phase III open label, two-arm, multicentre, pragmatic parallel group sequential randomised clinical trial with an internal pilot, looking to recruit adult patients with septic shock from the Emergency Department and Acute Assessment Units.
Our overall aim is to deliver a UK wide pragmatic multicentre randomised controlled trial to determine definitively whether early peripheral vasopressor infusion (PVI) targeted to MAP > 65mmHg is clinically and cost effective for adult patients with septic shock, compared with current usual care.
The primary objective is to determine whether early peripheral vasopressor infusion (PVI) with norepinephrine targeted to MAP of > 65 mmHg improves clinical effectiveness (30 day mortality) in hospitalised adult patients with septic shock compared with usual care, in the first 48 hours.
Treating patients with vasopressors when they arrive in the Emergency Department, may have potential advantages over the standard fluids used today. However, the evidence is not clear hence the need for EVIS.
Introduction to EVIS – Early Vasopressors in Sepsis from our Chief Investigator Alasdair Corfield
Navigating this site
All currently approved study documents, including the Participant Information Sheets and Consent forms, and those required by R&D departments and pharmacists, can be downloaded from the study tools area of the site. The study protocol can be freely downloaded here also.
All previous amendments which have been submitted can be found in the amendments area of the site. It is your responsibility to check which versions of the study documents are the current versions for your site (i.e. have local R&D approval in place).
The Study training area of the site contains all relevant modules and training materials needed in order for your local study staff to self-train on the EVIS Trial. This has been broken down by the role you will have in the local study team. The training matrix provided on this page provides an overview of the mandatory and recommended training you are required to complete. Please document all training undertaken on the EVIS Modules training log provided.
Randomisation is conducted on our eCRF REDCAP, and can be accessed via the Randomise a patient quick link.
